Noise and Air Pollution as Risk Factors for Hypertension: Part I—Epidemiology

Author:

Hahad Omar123,Rajagopalan Sanjay4ORCID,Lelieveld Jos5ORCID,Sørensen Mette67,Frenis Katie8ORCID,Daiber Andreas12ORCID,Basner Mathias9,Nieuwenhuijsen Mark10111213,Brook Robert D.14ORCID,Münzel Thomas12ORCID

Affiliation:

1. Department of Cardiology—Cardiology I, University Medical Center of the Johannes Gutenberg University Mainz, Germany (O.H., A.D., T.M.).

2. German Center for Cardiovascular Research (DZHK), partner site Rhine-Main, Mainz, Germany (O.H., A.D., T.M.).

3. Leibniz Institute for Resilience Research (LIR), Mainz, Germany (O.H.).

4. Harrington Heart and Vascular Institute, University Hospitals and Case Western Reserve University, Cleveland, OH (S.R.).

5. Atmospheric Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany (J.L.).

6. Environment and Cancer, Danish Cancer Society Research Center, Copenhagen, Denmark (M.S.).

7. Department of Natural Science and Environment, Roskilde University, Denmark (M.S.).

8. Boston Children’s Hospital and Harvard Medical School, Hematology/Oncology, Boston, MA (K.F.).

9. Department of Psychiatry, Unit for Experimental Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.B.).

10. Institute for Global Health (ISGlobal), Barcelona, Spain (M.N.).

11. Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain (M.N.).

12. CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain (M.N.).

13. Center for Urban Research, RMIT University, Melbourne VIC, Australia (M.N.).

14. Division of Cardiovascular Diseases, Department of Internal Medicine, Wayne State University, Detroit, MI (R.D.B.).

Abstract

Traffic noise and air pollution are 2 major environmental health risk factors in urbanized societies that often occur together. Despite cooccurrence in urban settings, noise and air pollution have generally been studied independently, with many studies reporting a consistent effect on blood pressure for individual exposures. In the present reviews, we will discuss the epidemiology of air pollution and noise effects on arterial hypertension and cardiovascular disease (part I) and the underlying pathophysiology (part II). Both environmental stressors have been found to cause endothelial dysfunction, oxidative stress, vascular inflammation, circadian dysfunction, and activation of the autonomic nervous system, thereby facilitating the development of hypertension. We also discuss the effects of interventions, current gaps in knowledge, and future research tasks. From a societal and policy perspective, the health effects of both air pollution and traffic noise are observed well below the current guideline recommendations. To this end, an important goal for the future is to increase the acceptance of environmental risk factors as important modifiable cardiovascular risk factors, given their substantial impact on the burden of cardiovascular disease.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Internal Medicine

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