Affiliation:
1. From the Department of Surgical and Perioperative Sciences, Urology and Andrology (T.S., P.S.), Department of Public Health and Clinical Medicine, Nutritional Research (G.H.), and Department of Radiation Sciences, Oncology (H.J.), Umeå University, Umeå, Sweden; Institute of Preventive Medicine (T.S.), Copenhagen University Hospital, Copenhagen, Denmark; King's College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group (M.V.H.), London, United Kingdom; Department of...
Abstract
Observational studies have shown inconsistent results for the association between blood pressure and cancer risk. We investigated the association in 7 cohorts from Norway, Austria, and Sweden. In total, 577799 adults with a mean age of 44 years were followed for, on average, 12 years. Incident cancers were 22184 in men and 14744 in women, and cancer deaths were 8724 and 4525, respectively. Cox regression was used to calculate hazard ratios of cancer per 10-mmHg increments of midblood pressure, which corresponded with 0.7 SDs and, for example, an increment of systolic/diastolic blood pressure of 130/80 to 142/88 mmHg. All of the models used age as the time scale and were adjusted for possible confounders, including body mass index and smoking status. In men, midblood pressure was positively related to total incident cancer (hazard ratio per 10 mmHg increment: 1.07 [95% CI: 1.04–1.09]) and to cancer of the oropharynx, colon, rectum, lung, bladder, kidney, malignant melanoma, and nonmelanoma skin cancer. In women, midblood pressure was not related to total incident cancer but was positively related to cancer of the liver, pancreas, cervix, uterine corpus, and malignant melanoma. A positive association was also found for cancer mortality, with HRs per 10-mmHg increment of 1.12 (95% CI: 1.08–1.15) for men and 1.06 (95% CI: 1.02–1.11) for women. These results suggest a small increased cancer risk overall in men with elevated blood pressure level and a higher risk for cancer death in men and women.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Cited by
209 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献