1. From the Institute for Clinical Evaluative Sciences and University Health Network (D.S.L.), University of Toronto, Toronto, Canada; National Heart, Lung, and Blood Institute’s Framingham Heart Study (J.M.M., T.J.W., W.B.K., E.J.B., S.K., D.L., R.B.D., R.S.V.), Framingham, Mass; Mathematics Department (J.M.M., R.B.D.), Boston University, Mass; Cardiology Division (T.J.W.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division (S.K.), University of California Irvine...