1. From the Second Department of Internal Medicine (T.Y., T.Mik., M.T., A.K., T.I., A.T., T.S., H.K., K.S., T.Miu.), Department of Pharmacology (A.K.), and Department of Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University, School of Medicine, Sapporo, Japan.