Vascular Function Is Improved After an Environmental Enrichment Program
-
Published:2018-06
Issue:6
Volume:71
Page:1218-1225
-
ISSN:0194-911X
-
Container-title:Hypertension
-
language:en
-
Short-container-title:Hypertension
Author:
Bruno Rosa Maria12, Stea Francesco12, Sicari Rosa2, Ghiadoni Lorenzo1, Taddei Stefano1, Ungar Andrea, Bonuccelli Ubaldo1, Tognoni Gloria3, Cintoli Simona3, Del Turco Serena2, Sbrana Silverio2, Gargani Luna2, D’Angelo Gennaro2, Pratali Lorenza2, Berardi Nicoletta4, Maffei Lamberto4, Picano Eugenio2, Andreassi M.G., Angelucci A., Baldacci F., Baroncelli L., Begenisic T., Bellinvia P.F., Biagi L., Bonaccorsi J., Bonanni E., Borghini A., Braschi C., Broccardi M., Caleo M., Carlesi C., Carnicelli L., Cartoni G., Cecchetti L., Cenni M.C., Ceravolo R., Chico L., Cioni G., Costa M., D’Ascanio P., De Nes M., Di Coscio E., Di Galante M., di Lascio N., Faita F., Falorni I, Faraguna U., Fenu A., Fortunato L., Franco R., Gargiulo R., Giorgi F.S., Iannarella R., Iofrida C., Kusmic C., Limongi F., Maestri M., Maffei M., Maggi S., Mainardi M., Mammana L., Marabotti A., Mariotti V., Melissari E., Mercuri A., Molinaro S., Narducci R., Navarra T., Noale M., Pagni C., Palumbo S., Pasquariello R., Pellegrini S., Pietrini P., Pizzorusso T., Poli A., Retico A., Ricciardi E., Rota G., Sale A., Scabia G., Scali M., Scelfo D., Siciliano G., Tonacci A., Tosetti M., Turchi S., Volpi L.,
Affiliation:
1. From the Department of Clinical and Experimental Medicine, University of Pisa, Italy (R.M.B., F.S., L.G., S.T., U.B.) 2. Institute of Clinical Physiology of the National Research Council (CNR), Pisa, Italy (R.M.B., F.S., R.S., S.D.T., S.S., L.G., G.D., L.P., E.P.) 3. Azienda Ospedaliero Universitaria Careggi, University of Florence, Italy (A.U.); Azienda Ospedaliero Universitaria Pisana, Italy (G.T., S.C.) 4. Institute of Neuroscience of CNR, Pisa, Italy (N.B., L.M.).
Abstract
Environmental enrichment may slow cognitive decay possibly acting through an improvement in vascular function. Aim of the study was to assess the effects of a 7-month cognitive, social, and physical training program on cognitive and vascular function in patients with mild cognitive impairment. In a single-center, randomized, parallel-group study, 113 patients (age, 65–89 years) were randomized to multidomain training (n=55) or usual care (n=58). All participants underwent neuropsychological tests and vascular evaluation, including brachial artery flow-mediated dilation, carotid–femoral pulse wave velocity, carotid distensibility, and assessment of circulating hematopoietic CD34+ and endothelial progenitor cells. At study entry, an age-matched control group (n=45) was also studied. Compared with controls, patients had at study entry a reduced flow-mediated dilation (2.97±2.14% versus 3.73±2.06%;
P
=0.03) and hyperemic stimulus (shear rate area under the curve, 19.1±15.7 versus 25.7±15.1×10
−3
;
P
=0.009); only the latter remained significant after adjustment for confounders (
P
=0.03). Training improved Alzheimer disease assessment scale cognitive (training, 14.0±4.8 to 13.1±5.5; nontraining, 12.1±3.9 to 13.2±4.8;
P
for interaction visit×training=0.02), flow-mediated dilation (2.82±2.19% to 3.40±1.81%, 3.05±2.08% to 2.24±1.59%;
P
=0.006;
P
=0.023 after adjustment for diameter and shear rate area under the curve), and circulating hematopoietic CD34
+
cells and prevented the decline in carotid distensibility (18.4±5.3 to 20.0±6.6, 23.9±11.0 to 19.5±7.1 Pa
−1
;
P
=0.005). The only clinical predictor of improvement of cognitive function after training was established hypertension. There was no correlation between changes in measures of cognitive and vascular function. In conclusion, a multidomain training program slows cognitive decline, especially in hypertensive individuals. This effect is accompanied by improved systemic endothelial function, mobilization of progenitor CD34
+
cells, and preserved carotid distensibility.
Clinical Trial Registration—
URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01725178.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Internal Medicine
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|