1. From the Departments of Pharmacology and Molecular Therapeutics (T.N., K.K., M.F., H.N., Y.T., Y.-F.D., S.K.-M.) and Cardiovascular Medicine (H.O.), Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan; Laboratory of Cell Signaling (H.I.), Tokyo University Graduate School of Pharmaceutical Sciences, Tokyo, Japan.