1. From the University of Alberta (P.W.A., Y.F., W.-C.C.), Edmonton, Alberta, Canada; the Cleveland Clinic Foundation (E.J.T.), Cleveland, Ohio; the Duke Clinical Research Institute (C.B.G., K.L.L., R.M.C.); Hospital Clinic (A.B.), University of Barcelona, Barcelona, Spain; and Universitaire Ziekenhuizen Leuven (F.V.d.W.), Leuven, Belgium.