Validation of a New Noncontact Catheter System for Electroanatomic Mapping of Left Ventricular Endocardium

Author:

Gornick Charles C.1,Adler Stuart W.1,Pederson Brian1,Hauck John1,Budd Jeffrey1,Schweitzer Jeff1

Affiliation:

1. From the University of Minnesota, Veterans Affairs Medical Center (C.C.G.), Minneapolis, Minn; St. Paul Heart Clinic (S.W.A.), St. Paul, Minn; and Endocardial Solutions Inc (B.P., J.H., J.B., J.S.), St. Paul, Minn.

Abstract

Background —Improvements in cardiac mapping are required to advance our understanding and treatment of arrhythmias. This study validated a new noncontact multielectrode array catheter and accompanying analysis system to provide electroanatomic mapping of the entire left ventricular (LV) endocardium during a single beat. Methods and Results —A 9F 64-electrode balloon array catheter with an inflated size of 1.8×4.6 cm was used to simultaneously record electrical potentials generated by the heart and locate a standard electrophysiology (EP) catheter within the same chamber. By use of the recorded location of the EP-catheter tip, LV geometry was determined. Array potentials served as inputs to a high-order boundary-element method to produce 3360 potential points on the endocardial surface translatable into electrograms or color-coded activation maps. Three methods of validation were used: (1) driven electrodes in an in vitro tank were located; (2) waveforms generated from the array catheter were compared with catheter contact waveforms in canine LV; and (3) sites of local LV endocardial activation were located and marked with radiofrequency lesions. Tank testing located a driven electrode to within 2.33±0.44 mm. Correlation of timing and morphology of computed versus contact electrograms was 0.966. Radiofrequency lesions marked 17 endocardial pacing sites to within 4.0±3.2 mm. Conclusions —This new system provides anatomically accurate endocardial isopotential mapping during a single cardiac cycle. The locator component enabled placement of a separate EP catheter to any site within the mapped chamber.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

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