Affiliation:
1. From the National Public Health Institute (J.H.S., J.P., C.E.), Helsinki, Finland; Department of Human Genetics (J.H.S., K.E.Z., C.F.S.), University of Michigan (Ann Arbor); and Department of Community Health and General Practice (A.N.), University of Kuopio, Finland.
Abstract
Background
There is ample evidence from cross-sectional studies of an association between allelic variation of the gene coding for apolipoprotein E (apoE) and interindividual variation in plasma lipids, and the presence of coronary heart disease (CHD). There have been no prospective studies, however, to evaluate the usefulness of allelic variation of the apoE gene for predicting CHD.
Methods and Results
Two samples of elderly Finnish men were followed for 5 years, one in the east (n=297) and the other in the southwest of Finland (n=369). At baseline, when the apoE genotypes were assessed, the men were 65 to 84 years old. At the end of the follow-up, the vital status of each man was determined, and cause of death was coded. At baseline, relative frequencies of the three alleles–ε2, ε3, and ε4–were 0.037, 0.827, and 0.136 in the eastern and 0.062, 0.763, and 0.175 in the southwestern samples, respectively (χ
2
=8.89,
df
=2,
P
<.012 for difference between the samples). During the 5-year follow-up, a total of 28 deaths from CHD were recorded in the eastern and 42 in the southwestern sample. Relative CHD mortality was not heterogeneous between the samples. Among those who died from CHD, there was a doubling of the relative ε4 allele frequency in both samples (χ
2
=4.70,
df
=1,
P
<.03 for the eastern sample; χ
2
=7.11,
df
=1,
P
<.01 for the southwestern sample).
Conclusions
Allelic variation in the apoE gene is a statistically significant predictor of CHD death in these samples of elderly Finnish men.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
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