1. From the Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory, Department of Medicine (Cardiovascular Division [A.C., H.S., S.E.K., J.P.M., P.S.D.] and Endocrinology [A.C.M.]), Beth Israel Hospital and Harvard Medical School, Boston, Mass; and Genentech Inc (R.C.), South San Francisco, Calif.