Sex, Age, Cardiovascular Risk Factors, and Coronary Heart Disease

Author:

Jousilahti Pekka1,Vartiainen Erkki1,Tuomilehto Jaakko1,Puska Pekka1

Affiliation:

1. From the National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland.

Abstract

Background —Coronary heart disease (CHD) is markedly more common in men than in women. In both sexes, CHD risk increases with age, but the increase is sharper in women. We analyzed the extent to which major cardiovascular risk factors can explain the sex difference and the age-related increase in CHD risk. Methods and Results —The study cohort consists of 14 786 Finnish men and women 25 to 64 years old at baseline. The following cardiovascular risk factors were determined: smoking, serum total cholesterol, HDL cholesterol, blood pressure, body mass index, and diabetes. Risk factor measurements were done in 1982 or 1987, and the cohorts were followed up until the end of 1994. The Cox proportional hazards model was used to assess the relation between risk factors and CHD risk. CHD incidence in men compared with women was ≈3 times higher and mortality was ≈5 times higher. Most of the risk factors were more favorable in women, but the sex difference in risk factor levels diminished with increasing age. Differences in risk factors between sexes, particularly in HDL cholesterol and smoking, explained nearly half of the difference in CHD risk between men and women. Differences in serum total cholesterol level, blood pressure, body mass index, and diabetes prevalence explained about one-third of the age-related increase in CHD risk among men and 50% to 60% among women. Conclusions —Differences in major cardiovascular risk factors explained a substantial part of the sex difference in CHD risk. An increase in risk factor levels was associated with the age-related increase in CHD incidence and mortality in both sexes but to a larger extent in women.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference47 articles.

1. Epidemiology of coronary heart disease: The Framingham study

2. Thom TJ Epstein FH Feldman JJ Leaverton PE Wolz M. Total Mortality and Mortality From Heart Disease Cancer and Stroke From 1950 to 1987 in 27 Countries . Bethesda Md: National Institutes of Health 1992. NIH publication 92–3088.

3. Coronary Artery Disease in Women

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