Author:
Serruys Patrick W.,di Mario Carlo,Piek Jan,Schroeder Erwin,Vrints Christian,Probst Peter,de Bruyne Bernard,Hanet Claude,Fleck Eckart,Haude Michael,Verna Edoardo,Voudris Vasilis,Geschwind Herbert,Emanuelsson Håkan,Mühlberger V.,Danzi Giambattista,Peels Hans O.,Ford Andrew J.,Boersma Eric
Abstract
Background
The aim of this prospective, multicenter study was the identification of Doppler flow velocity measurements predictive of clinical outcome of patients undergoing single-vessel balloon angioplasty with no previous Q-wave myocardial infarction.
Methods and Results
In 297 patients, a Doppler guidewire was used to measure basal and maximal hyperemic flow velocities proximal and distal to the stenosis before and after angioplasty. In 225 patients with an angiographically successful percutaneous transluminal coronary angioplasty (PTCA), postprocedural distal coronary flow reserve (CFR) and percent diameter stenosis (DS%) were correlated with symptoms and/or ischemia at 1 and 6 months, with the need for target lesion revascularization, and with angiographic restenosis (defined as DS ≥50% at follow-up). Logistic regression and receiver operator characteristic curve analyses were applied to determine the prognostic cutoff value of CFR and DS separately and in combination. Optimal cutoff criteria for predictors of these clinical events were DS, 35%; CFR, 2.5. A distal CFR after angioplasty >2.5 with a residual DS ≤35% identified lesions with a low incidence of recurrence of symptoms at 1 month (10% versus 19%,
P
=.149) and at 6 months (23% versus 47%,
P
=.005), a low need for reintervention (16% versus 34%,
P
=.024), and a low restenosis rate (16% versus 41%,
P
=.002) compared with patients who did not meet these criteria.
Conclusions
Measurements of distal CFR after PTCA, in combination with DS%, have a predictive value, albeit modest for the short- and long-term outcomes after PTCA, and thus may be used to identify patients who will or will not benefit from additional therapy such as stent implantation.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Cited by
187 articles.
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