1. From the Department of Medical Biochemistry (B.C., S.R.C., V.B.O.) and the Department of Pharmacology, Therapeutics, and Toxicology (M.J.L.), University of Wales College of Medicine, Cardiff, UK; the Department of Molecular and Experimental Medicine (A.R.C.), The Scripps Research Institute, La Jolla, Calif; and the Departments of Anesthesiology, Biochemistry, and Molecular Genetics and the Center for Free Radical Biology (A.B., B.A.F.), University of Alabama at Birmingham.