1. From the Departments of Molecular Cardiovascular Research and Cardiology (A.Z., A.S., P.v.H., E.A.L., C.W.), University Hospital, Rheinisch-Westfälische Technische Hochschule, Aachen, Germany; Division of Biopharmaceutics (I.B., E.A.B.), Gorlaeus Laboratories, Leiden University, The Netherlands; Department of Pharmacology and Toxicology (B.M., P.G.), University of Ulm, Germany; and Physiology and Physiopathology Unit (M.M.), Pierre and Marie Curie University (PARIS 6), France.