1. From the Department of Pharmacology (R.M., D.A.C., J.F., E.S.F, M.M.C., J.B.C), Universidade Federal de Santa Catarina, Brazil; Department of Pharmacology (M.C.W.A) and Department of Biophysics (M.A.S.M., J.B.P.), Universidade Federal de São Paulo, Brazil; Max Delbrück Centre for Molecular Medicine (D.A.C., M.B.), Berlin-Buch, Germany.