1. From the Division of Cellular and Molecular Biology (X.-M.Y., W.K., T.A., B.R., A.M.S., R.G., M.H.), The Toronto General Hospital Research Institute; Heart and Stroke Richard Lewar Centre of Excellence (I.N.M., R.G., M.H.) and the Departments of Medicine, and Laboratory Medicine and Pathobiology (I.N.M., M.H.), University of Toronto, Ontario, Canada.