1. From the VA Western New York Health Care System (J.M.C.Jr., M.B., J.A.F.) and the Departments of Medicine (J.M.C.Jr., G.S., M.D.B., J.A.F.) and Physiology/Biophysics (J.M.C.Jr.), University at Buffalo, Buffalo, NY, and the Department of Pathology and Cellular and Molecular Biology (F.V.), Cardiovascular Research Institute, University of Maastricht, The Netherlands.