Five‐Year Risk of Acute Myocardial Infarction After Acute Ischemic Stroke in Korea

Author:

Lee Keon‐Joo1,Kim Seong‐Eun1,Kim Jun Yup1ORCID,Kang Jihoon1ORCID,Kim Beom Joon1ORCID,Han Moon‐Ku1ORCID,Choi Kang‐Ho2ORCID,Kim Joon‐Tae2,Shin Dong‐Ick3,Cha Jae‐Kwan4,Kim Dae‐Hyun4,Kim Dong‐Eog5,Ryu Wi‐Sun5,Park Jong‐Moo6,Kang Kyusik6ORCID,Kim Jae Guk7,Lee Soo Joo7,Oh Mi‐Sun8ORCID,Yu Kyung‐Ho8,Lee Byung‐Chul8,Park Hong‐Kyun9ORCID,Hong Keun‐Sik9,Cho Yong‐Jin9,Choi Jay Chol10ORCID,Sohn Sung Il11ORCID,Hong Jeong‐Ho11,Park Moo‐Seok12,Park Tai Hwan12,Park Sang‐Soon12,Lee Kyung Bok13,Kwon Jee‐Hyun14,Kim Wook‐Joo14,Lee Jun15,Lee Ji Sung16ORCID,Lee Juneyoung17,Gorelick Philip B.1819ORCID,Bae Hee‐Joon1ORCID,

Affiliation:

1. Department of Neurology and Cerebrovascular Center Seoul National University Bundang HospitalSeoul National University College of Medicine Seongnam Republic of Korea

2. Department of Neurology Chonnam National University Hospital Gwangju Republic of Korea

3. Department of Neurology Chungbuk National University Hospital Cheongju Republic of Korea

4. Department of Neurology Dong‐A University HospitalDong‐A University College of Medicine Busan Republic of Korea

5. Department of Neurology Dongguk University Ilsan Hospital Goyang Republic of Korea

6. Department of Neurology Eulji General Hospital Seoul Republic of Korea

7. Department of Neurology Eulji University HospitalEulji University Daejeon Republic of Korea

8. Department of Neurology Hallym University Sacred Heart Hospital Anyang Republic of Korea

9. Department of Neurology Ilsan Paik HospitalInje University Goyang Republic of Korea

10. Department of Neurology Jeju National University HospitalJeju National University School of Medicine Jeju Republic of Korea

11. Department of Neurology Keimyung University Dongsan Medical Center Daegu Republic of Korea

12. Department of Neurology Seoul Medical Center Seoul Republic of Korea

13. Department of Neurology College of Medicine Soonchunhyang University Hospital Seoul Republic of Korea

14. Department of Neurology Ulsan University HospitalUlsan University College of Medicine Ulsan Republic of Korea

15. Department of Neurology Yeungnam University Hospital Daegu Republic of Korea

16. Clinical Research Center Asan Medical Center Seoul Republic of Korea

17. Department of Biostatistics Korea University College of Medicine Seoul Republic of Korea

18. Davee Department of Neurology Feinberg School of Medicine Chicago IL

19. Department of Translational Neuroscience College of Human Medicine Michigan State University Grand Rapids MI

Abstract

Background The long‐term incidence of acute myocardial infarction (AMI) in patients with acute ischemic stroke (AIS) has not been well defined in large cohort studies of various race‐ethnic groups. Methods and Results A prospective cohort of patients with AIS who were registered in a multicenter nationwide stroke registry (CRCS‐K [Clinical Research Collaboration for Stroke in Korea] registry) was followed up for the occurrence of AMI through a linkage with the National Health Insurance Service claims database. The 5‐year cumulative incidence and annual risk were estimated according to predefined demographic subgroups, stroke subtypes, a history of coronary heart disease (CHD), and known risk factors of CHD. A total of 11 720 patients with AIS were studied. The 5‐year cumulative incidence of AMI was 2.0%. The annual risk was highest in the first year after the index event (1.1%), followed by a much lower annual risk in the second to fifth years (between 0.16% and 0.27%). Among subgroups, annual risk in the first year was highest in those with a history of CHD (4.1%) compared with those without a history of CHD (0.8%). The small‐vessel occlusion subtype had a much lower incidence (0.8%) compared with large‐vessel occlusion (2.2%) or cardioembolism (2.4%) subtypes. In the multivariable analysis, history of CHD (hazard ratio, 2.84; 95% CI, 2.01–3.93) was the strongest independent predictor of AMI after AIS. Conclusions The incidence of AMI after AIS in South Korea was relatively low and unexpectedly highest during the first year after stroke. CHD was the most substantial risk factor for AMI after stroke and conferred an approximate 5‐fold greater risk.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3