Radioautographic Study of Aortic Plaque Formation

Author:

FELS I. GORDON1,THADDEUS KANABROCKI1

Affiliation:

1. Radioisotope Service, Veterans Administration, Edward Hines, Jr., Hospital, Hines, Ill.

Abstract

Radioautographic evidence using Ca 45 Cl 2 is presented to demonstrate that the aorta has an inherent ability to bind calcium ion regardless of age, sex or species. The binding occurs primarily in the intima and is not homogeneously distributed. Experiments with boiled aorta suggest that the primary substance responsible is collagen. The binding of calcium by the aorta has a marked effect upon the stability of emulsions. A theory of arterial plaque formation is presented.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference11 articles.

1. GREEXBERG D. M.: Interaction between the alkali earth cations particularly calcium and proteins. In Advances in Protein Chemistry. Xew York Academic Press Vol. 1 pp. 121-151 1944.

2. The Theory of Emulsification, I

3. Demineralization of Hard Tissues by Organic Chelating Agents

4. The collagen hydroxyapatite system as studied in vitro;GLIIICHER M. J.;Proe. Xat. Acad. Sc.,1957

5. The Human Aorta. Sulfate containing polyuronides and the deposition of cholesterol;FABER M.;Arch. Path.,1949

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