Affiliation:
1. From the Department of Surgery, University of Colorado Health Sciences Center, Denver.
Abstract
Abstract
Catecholamines have been implicated in the phenomenon of ischemic preconditioning. We have previously demonstrated that ischemic preconditioning against postischemic mechanical dysfunction in the isolated rat heart is mediated by the α
1
-adrenergic receptor. The purpose of this study was to delineate the signal transduction of preconditioning distal to the α
1
-adrenergic receptor. Our results suggest that (1) transient ischemia and α
1
-adrenergic receptor–induced preconditioning is inhibited by protein kinase C (PKC) antagonists, (2) functional protection against global ischemia/reperfusion injury can be induced by infusion of diacylglycerol, the second messenger of the α
1
-adrenergic pathway, and (3) transient ischemia and α
1
-adrenergic preconditioning are both characterized by similar translocation of PKC-δ to the sarcolemma of myocardium. These findings suggest that PKC is an effector of preconditioning in the isolated rat heart.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Reference57 articles.
1. Reimer KA Jennings RB. Preconditioning: definitions proposed mechanisms and implications for myocardial protection in ischemia and reperfusion. In: Yellon DM Jennings RB eds. Myocardial Protection: The Pathophysiology of Reperfusion and Reperfusion Injury . New York NY: Raven Press Publishers; 1992:165-183.
2. Ischaemic preconditioning: from mechanisms to exploitation
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