Affiliation:
1. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505.
Abstract
The goal of this study was to determine if there is a basal release of nitric oxide that affects long-term arterial pressure regulation in dogs. Studies were conducted over a 23-day period in eight conscious dogs with indwelling catheters. Nitric oxide synthesis was blocked by continuous intravenous infusion of nitro-L-arginine-methyl ester at 37.1 nmol/kg per minute for 11 days. Arterial pressure increased to 120 +/- 4% of control on the first day, decreased for a few days, and then increased to a maximum value of 122 +/- 6% of control on day 7. Bradycardia was sustained throughout the entire nitro-arginine period. Blockade of nitric oxide synthesis was evidenced by attenuated pressure and flow responses to systemic acetylcholine infusion. The pressor response to phenylephrine was increased for only 1 day, and the hypotensive effects of nitroprusside were enhanced. Also, the variability of arterial pressure was significantly increased during nitro-arginine. Sodium and water balances were positive the first day of nitro-arginine infusion but were unchanged for the entire nitro-arginine period. In conclusion, the data suggest that blockade of the basal release of nitric oxide in dogs causes an increase in the long-term level of arterial pressure without any sustained sodium or water retention.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Reference33 articles.
1. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
2. Furchgott RF. Studies on relaxation of rabbit aorta by sodium nitrite: the basis for the proposal that the acid-activatable inhibitory factor from retractor penis is inorganic nitrite and the endothelium-derived relaxing factor is nitric oxide. In: Vanhoutte PM ed. Vasodilatation: Vascular Smooth Muscle Peptides Autonomic Nerves and Endothelium. New York NY: Raven Press Publishers; 1988:401-414.
3. Ignarro LG Buga GM Wood KS Byrns RE Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA. 9265-9269.
4. 1987;84
:
5. A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells
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