Lead Increases Aldosterone Production by Rat Adrenal Cells

Author:

Goodfriend Theodore L.1,Ball Dennis L.1,Elliott Mary E.1,Shackleton Cedric1

Affiliation:

1. From the William S. Middleton Memorial Veterans Hospital and the Departments of Pharmacology and Medicine, University of Wisconsin, Madison (T.L.G., D.L.B., M.E.E.), and the Children’s Hospital Research Institute, Oakland, Calif (C.S.).

Abstract

Abstract Exposure to lead has been postulated to contribute to elevated blood pressure in humans and has been shown to raise blood pressure in animals. The mechanism of action of lead on blood pressure is unknown. We fed lead to rats in their drinking water and then examined the production of aldosterone by their adrenal cells in vitro. We also measured excretion of aldosterone and corticosterone by intact rats stimulated with corticotropin, with and without lead treatment. At a dose (273 ppm) that raised blood levels to 30 to 40 μg/dL, comparable to blood levels in exposed humans, lead induced increased aldosterone secretion in vitro and in vivo. The effect of lead was most evident when cells or animals were stimulated with aldosterone secretagogues. Experiments in vitro indicate that exposure to lead in vivo increases activity of one or more steps in the late pathway of aldosterone biosynthesis. The results suggest that the hypertensive effect of lead involves relative hyperaldosteronism and may be most evident when secretion of this hormone is stimulated.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Internal Medicine

Reference14 articles.

1. Elias RW. Lead exposures in the human environment. In: Maffey KR ed. Dietary and Environmental Lead: Human Health Effects . New York NY: Elsevier Science Publishing Co; 1985:79-107.

2. Epidemiology of hypertension as a public health problem: an overview as background for evaluation of blood lead-blood pressure relationship.

3. Schwartz J. Lead blood pressure and cardiovascular disease. In: Needleman HL ed. Human Lead Exposure . Boca Raton Fla: CRC Press; 1992:223-232.

4. Blood lead and blood pressure: some implications for the situation in The Netherlands.

5. The relationship of blood lead levels and blood pressure in NHANES II: additional calculations.

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