Renomedullary deficiency in partial nephrectomy-salt hypertension.

Author:

Pitcock J A,Brown P S,Brooks B,Clapp W L,Brosius W L,Muirhead E E

Abstract

Partial nephrectomy-salt hypertension (PN-SH) of the rat is associated with Na volume loading. As the hypertensive state evolves, the renomedullary interstitial cells (RIC) of the renal nubbin undergo major changes, decreasing significantly in number while the remaining ones exhibit degenerative changes. The antihypertensive action of the RIC in the renal nubbin, as measured by transplants of fragmented papillae into hypertensive recipients, virtually disappears as the hypertension develops. The changes in the RIC occur whether vascular disease of the kidney is or is not overtly present. It is suggested that deficiency of the antihypertensive action of the RIC allows the prohypertensive effects of Na volume loading to operate without proper control. Thus, the sustained hypertensive state of this model does not appear to be due solely to volume expansion. Rather, it appears due to a combination of the effects of Na and volume and a renomedullary deficiency of hormonal type. The specific cause(s) of the changes in the RIC was not determined. It seems evident that it is related to the high salt intake since the partial nephrectomy procedure without the added salt load did not alter the appearance of the RIC.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Internal Medicine

Reference42 articles.

1. Vasoconstriction-volume analysis for understanding and treating hypertension: The use of renin and aldosterone profiles

2. Physiologic characteristics of hypertension

3. Vasopressin and malignant desoxycorticosterone hypertension in rats;Mohring J;Clin Sci Mol Med,1976

4. Clinical hemodynamics and pharmacodynamics of toxemia;Finnerty;Circulation,1964

5. Braun-Menendez E Von Euler US: Hypertension bilateral nephrectomy in the rat. Nature 160: 905 1947 after

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