Affiliation:
1. The George Institute for Global Health University of Oxford, Oxford, United Kingdom
2. The George Institute for Global Health University of New South Wales, Sydney, Australia
3. Department of Epidemiology, Johns Hopkins University, Baltimore, MD
Abstract
Background
There are substantial differences in the distribution of adipose tissue between women and men. We assessed the sex‐specific relationships and their differences between measures of general and central adiposity and the risk of incident myocardial infarction (
MI
).
Methods and Results
Between 2006 and 2010, the
UK
Biobank recruited over 500 000 participants aged 40 to 69 years across the United Kingdom. During 7 years of follow‐up, 5710 cases of
MI
(28% women) were recorded among 265 988 women and 213 622 men without a history of cardiovascular disease at baseline. Cox regression models yielded adjusted hazard ratios for
MI
associated with body mass index, waist circumference, waist‐to‐hip ratio, and waist‐to‐height ratio. There was an approximate log‐linear relationship between measures of general and central adiposity and the risk of
MI
in both sexes. A 1‐
SD
higher in body mass index, waist circumference, waist‐to‐hip ratio, and waist‐to‐height ratio, respectively, were associated with hazard ratios (confidence intervals) for
MI
of 1.22 (1.17; 1.28), 1.35 (1.28; 1.42), 1.49 (1.39; 1.59), and 1.34 (1.27; 1.40) in women and of 1.28 (1.23; 1.32), 1.28 (1.23; 1.33), 1.36 (1.30; 1.43), and 1.33 (1.28; 1.38) in men. The corresponding women‐to‐men ratios of hazard ratios were 0.96 (0.91; 1.02), 1.07 (1.00; 1.14), 1.15 (1.06; 1.24), and 1.03 (0.97; 1.09).
Conclusions
Although general and central adiposity measures each have profound deleterious effects on the risk of
MI
in both sexes, a higher waist circumference and waist‐to‐hip ratio conferred a greater excess risk of
MI
in women than in men. Waist‐to‐hip ratio was more strongly associated with the risk of
MI
than body mass index in both sexes, especially in women.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
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