Citric Acid Cycle Intermediates in Cardioprotection

Author:

Czibik Gabor1,Steeples Violetta1,Yavari Arash1,Ashrafian Houman1

Affiliation:

1. From the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

Abstract

Over the last decade, there has been a concerted clinical effort to deliver on the laboratory promise that a variety of maneuvers can profoundly increase cardiac tolerance to ischemia and/or reduce additional damage consequent upon reperfusion. Here we will review the proximity of the metabolic approach to clinical practice. Specifically, we will focus on how the citric acid cycle is involved in cardioprotection. Inspired by cross-fertilization between fundamental cancer biology and cardiovascular medicine, a set of metabolic observations have identified novel metabolic pathways, easily manipulable in man, which can harness metabolism to robustly combat ischemia-reperfusion injury.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Genetics (clinical),Cardiology and Cardiovascular Medicine,Genetics

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