Affiliation:
1. Department of Surgery, Tulane University School of Medicine, New Orleans 70112.
Abstract
Prostaglandin (PG) formation in 16 atherosclerotic human carotid endarterectomy specimens was compared systematically with that of normal carotid artery from seven white pigs and six rhesus monkeys. Prostacyclin (PGI2) formation (picomoles 6-keto-PGF1a/2 min/100 micrograms homogenate protein plus 2 mM glutathione [GSH]) of nonatheromatous intima adjacent proximal (276 +/- 32, mean +/- SEM) or distal (271 +/- 14) to carotid plaque was comparable to that of normal carotid artery from white pig (272 +/- 25, NS) and rhesus monkey (219 +/- 41, NS), and was greater than stenotic intima (156 +/- 17, p less than 0.01), subintimal plaque (168 +/- 14, p less than 0.01), and ulceration (65 +/- 16, p less than 0.01). GSH modulated PGI2 synthesis in all carotid specimens except areas of ulceration (p less than 0.05), but did not restore PGI2 formation in atheromatous fractions to basal level. No detectable arterial thromboxane A2 (TXA2) formation or GSH-dependent PGE2 isomerase activity was observed. The decrement in atherosclerotic carotid artery PGI2 formation was focal (confined to the plaque) and may have been related to loss of effective GSH modulation. These conditions could contribute to a localized imbalance between arterial PGI2 and platelet TXA2 with adverse vascular thromboregulatory consequences.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Reference24 articles.
1. Moncada S. Prostacyclin/thromboxane-mediated mechanisms in platelet-vascular wall Interactions. In: Hayaishi O Yamamoto S eds. Advances in prostaglandin thromboxane and leukotriene research vol 15. New York: Raven Press 1985:507-512
2. by different types of human atherosclerotic lesions;Slnzlnger H;Exp Pathol,1980
3. Prostacyclin formation by human aorta in different types of atherosclerotic lesions;Gellng NG;Biomed Biochlm Ada,1984
4. Alteration in prostacyclin and prostaglandin E2 production. Correlation with changes in human aortic atherosclerotic disease.
5. Qamache FW Weksler BB Patterson RH. Prostacyclin and thromboxane production by temporal artery and carotid plaque [abstr]. (Abstracts of the Tenth International Joint Conference on Stroke and Circulation) Stroke 1985;16:140 (abstract 20)
Cited by
31 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献