Affiliation:
1. From the Laboratory of Hematology, CHU Timone (P.E.M., M.C.A., M.V., I.J.-V.), and the Department of Plastic Surgery, CHU Conception (D.C., G.M.), Marseille, France.
Abstract
Abstract
—Human adipose tissue has been shown to produce plasminogen activator inhibitor type 1 (PAI-1). However, the importance of adipose tissue in the regulation of the PAI-1 plasma level is not known. The aim of this study was to investigate the relation between the production of PAI-1 by adipose tissue, plasma PAI-1 level, and variables related to the insulin resistance state. The link between the production of PAI-1 inducers such as tumor necrosis factor-α and transforming growth factor-β and the production of PAI-1 by adipose tissue was also evaluated. Blood samples were obtained as soon as possible to the induction of anesthesia from 30 patients undergoing elective abdominoplasty. PAI-1 antigen levels measured in conditioned media after a 19-hour incubation period of adipose tissue explants were significantly correlated with plasma PAI-1 antigen levels (
r
=0.54,
P
=0.004) and with systemic lipid parameters such as triglycerides and high density lipoprotein cholesterol (
r
=0.46,
P
=0.014;
r
=−0.50,
P
=0.01, respectively) but not with insulinemia and body mass index. PAI-1 production by adipose tissue was correlated with those of TNF-α (
r
=0.5,
P
=0.01) and TGF-β (
r
=0.53,
P
=0.007). These results emphasize the role of adipose tissue in determining plasma levels of PAI-1, with a local contribution of TNF-α and TGF-β in PAI-1 production by adipose tissue.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
91 articles.
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