Apolipoprotein E Alleles and Risk of Coronary Disease

Author:

Wilson Peter W.F.1,Schaefer Ernst J.1,Larson Martin G.1,Ordovas Jose M.1

Affiliation:

1. the Framingham Heart Study, National Heart, Lung, and Blood Institute (P.W.F.W.) and Boston University (M.G.L.), Framingham, and Tufts USDA Nutrition Center, Boston (E.J.S., J.M.O.), Mass.

Abstract

A meta-analysis was undertaken to assess the impact of apolipoprotein E (apo E) alleles (ε2, ε3, and ε4) on coronary disease in 14 published observational studies (9 clinical coronary disease and 5 coronary angiography). In comparison with ε3, the ε4 allele was associated with greater odds for coronary heart disease, and summary estimates of the odds ratios (ORs) and (95% confidence intervals) for both sexes combined were OR=0.98 (0.85-1.14) for ε2 and OR=1.26 (1.13-1.41) for ε4. Separate analyses for men and women showed similar associations. In angiographic studies the relative odds for significant coronary artery disease among both sexes combined was OR=0.76 (0.55-1.05) for ε2 and OR=1.11 (0.88-1.40) for ε4. The overall impression is that ε4 is associated with clinical and coronary disease and that results are similar in men and women.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Reference42 articles.

1. Apolipoprotein E polymorphism and atherosclerosis.

2. Davignon J. Apolipoprotein E polymorphism and atherosclerosis. In: Born GVR Schwartz CJ eds. New Horizons in Coronary Heart Disease . London England: Current Science; 1993:5.1-5.21.

3. Polymorphism of apolipoprotein E

4. Polymorphism of apolipoprotein E

5. Relation of apolipoprotein E phenotype to myocardial infarction and mortality from coronary artery disease

Cited by 477 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3