Cardiovascular Pharmacogenomics-Reference-Cited by-同舟云学术

Cardiovascular Pharmacogenomics

Published:2011-09-16 Issue:7 Volume:109 Page:807-820
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circ Res

Author:

Roden Dan M.¹,Johnson Julie A.¹,Kimmel Stephen E.¹,Krauss Ronald M.¹,Medina Marisa Wong¹,Shuldiner Alan¹,Wilke Russell A.¹

Affiliation:

1. From the Departments of Medicine and Pharmacology (D.M.R., R.A.W.), Vanderbilt University School of Medicine, Nashville, TN; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (J.A.J.), College of Pharmacy, University of Florida, Gainesville, FL; Center for Clinical Epidemiology and Biostatistics (S.E.K.), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA; Children's Hospital Oakland Research Institute ...

Abstract

Patients vary in their responses to drug therapy, and some of that variability is genetically determined. This review outlines general approaches used to identify genetic variation that influences drug response. Examples from specific therapeutic areas are presented, such as cholesterol management, arrhythmias, heart failure, hypertension, warfarin anticoagulation, and antiplatelet agents. A brief view of potential pathways to implementation is presented.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.110.230995

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