1. From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada.