Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1-Reference-Cited by-同舟云学术

Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1

Published:2018-07-20 Issue:3 Volume:123 Page:342-355
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circ Res

Author:

Hopf Anna-Eliane¹,Andresen Christian¹,Kötter Sebastian¹,Isić Małgorzata¹,Ulrich Kamila²,Sahin Senem¹,Bongardt Sabine¹,Röll Wilhelm³,Drove Felicitas⁴,Scheerer Nina⁴,Vandekerckhove Leni⁵,De Keulenaer Gilles W.⁵,Hamdani Nazha²,Linke Wolfgang A.⁶,Krüger Martina¹

Affiliation:

1. From the Medical Faculty, Department of Cardiovascular Physiology, Heinrich-Heine-University, Düsseldorf, Germany (A.-E.H., C.A., S.K., M.I., S.S., S.B., M.K.)

2. Department of Systems Physiology, Ruhr-University Bochum, Germany (K.U., N.H.)

3. Department of Cardiovascular Surgery, University Clinic Bonn, Germany (W.R.)

4. Bayer AG, Drug Discovery, Pharmaceuticals, Wuppertal, Germany (F.D., N.S.)

5. Department of Pharmaceutical Sciences, Laboratory of Physiopharmacology, Campus Drie Eiken, University of Antwerp, Belgium (L.V., G.W.D.)

6. Institute of Physiology II, University of Munster, Germany (W.A.L.).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference35 articles.

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2. Diastolic Stiffness of the Failing Diabetic Heart

3. Diabetes Mellitus Worsens Diastolic Left Ventricular Dysfunction in Aortic Stenosis Through Altered Myocardial Structure and Cardiomyocyte Stiffness

4. Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4

5. Myocardial Titin Hypophosphorylation Importantly Contributes to Heart Failure With Preserved Ejection Fraction in a Rat Metabolic Risk Model

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