Whole Exome Sequencing Reveals the Major Genetic Contributors to Nonsyndromic Tetralogy of Fallot

Author:

Page Donna J.1,Miossec Matthieu J.23,Williams Simon G.1,Monaghan Richard M.1,Fotiou Elisavet1,Cordell Heather J.2,Sutcliffe Louise,Topf Ana2,Bourgey Mathieu45,Bourque Guillaume5,Eveleigh Robert5,Dunwoodie Sally L.678,Winlaw David S.91011,Bhattacharya Shoumo1112,Breckpot Jeroen1213,Devriendt Koenraad12,Gewillig Marc13,Brook J. David14,Setchfield Kerry J.14,Bu’Lock Frances A.15,O’Sullivan John16,Stuart Graham17,Bezzina Connie R.18,Mulder Barbara J.M.19,Postma Alex V.20,Bentham James R.21,Baron Martin22,Bhaskar Sanjeev S.23,Black Graeme C.23,Newman William G.24,Hentges Kathryn E.,Lathrop G. Mark5,Santibanez-Koref Mauro2,Keavney Bernard D.1

Affiliation:

1. From the Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom (D.J.P., S.G.W., R.M.M., E.F., B.D.K.)

2. Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom (M.J.M., H.J.C., L.S., A.T., M.S.-K.)

3. Center for Bioinformatics and Integrative Biology, Faculty of Biological Sciences, Universidad Andrés Bello, Santiago, Chile (M.J.M.)

4. Canadian Centre for Computational Genomics, Montréal, QC, Canada (M.B.)

5. McGill Genome Center, Montréal, QC, Canada (M.B., G.B., R.E., G.M.L.)

6. Chain Reaction Program in Congenital Heart Disease Research, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia (S.L.D.)

7. Faculties of Medicine and Science, University of New South Wales, Sydney (S.L.D.)

8. Heart Centre for Children, The Children’s Hospital at Westmead, Sydney, NSW (S.L.D.)

9. School of Child and Adolescent Health, Sydney Medical School, University of Sydney (D.S.W.)

10. Victor Chang Cardiac Research Institute, NSW, Australia (D.S.W.)

11. RDM Cardiovascular Medicine, Wellcome Centre for Human Genetics, University of Oxford (D.S.W., S.B.)

12. Center for Human Genetics, Catholic University Leuven, Belgium (S.B., J.B., K.D.)

13. Pediatric and Congenital Cardiology, UZ Leuven (J.B., M.G.)

14. School of Life Sciences, University of Nottingham, Queen’s Medical Centre (J.D.B., K.J.S.)

15. Congenital and Paediatric Cardiology, East Midlands Congenital Heart Centre and University of Leicester, Glenfield Hospital (F.A.B.)

16. Adult Congenital and Paediatric Cardiac Unit, Freeman Hospital, Newcastle upon Tyne (J.O.)

17. University Hospitals Bristol NHS Foundation Trust, Bristol (G.S.)

18. Heart Center, Department of Clinical and Experimental Cardiology (C.R.B.), Academic Medical Center, Amsterdam, the Netherlands

19. Department of Medical Biology (B.J.M.M.), Academic Medical Center, Amsterdam, the Netherlands

20. Department of Clinical Genetics (A.V.P.), Academic Medical Center, Amsterdam, the Netherlands

21. Department of Paediatric Cardiology, Yorkshire Heart Centre, Leeds (J.R.B.)

22. Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester (M.B.)

23. Manchester Centre for Genomic Medicine, Saint Mary’s Hospital, Oxford, Manchester (S.S.B., G.C.B.)

24. Division of Evolution and Genomic Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford (W.G.N.); and Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, UK.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

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