1. From the Centre for Pharmacology and Therapeutics (V.B.A.-S., G.R., C.C.-N., A.S.M., M.R.W., L.Z., M.G., O.D., B.W.-S.), Department of Medicine, Imperial College London, United Kingdom
2. Section of Structural Biology (L.A.Y.), Department of Medicine, Imperial College London, United Kingdom
3. Silence Therapeutics GmbH, Berlin, Germany (U.S., J.E.).