1. From the Fachbereich Biologie (K.P.), Chemie, Pharmazie, Freie Universität Berlin, Germany; Leibniz-Institut für Molekulare Pharmakologie (K.P., E.K., X.S., G.K., W.-E.S.), Berlin, Germany; Department of Cardiology and Pneumology (Y.W., F.G., H.-P.S., T.W.), Campus Benjamin Franklin, Charité-Universitätsmedizin, Berlin, Germany; and Department of Pharmacology (F.G., T.W.), Erasmus Medical Center, Rotterdam, The Netherlands.