Regulatory Role of G Protein–Coupled Estrogen Receptor for Vascular Function and Obesity-Reference-Cited by-同舟云学术

Regulatory Role of G Protein–Coupled Estrogen Receptor for Vascular Function and Obesity

Published:2009-02-13 Issue:3 Volume:104 Page:288-291
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

Haas Elvira¹,Bhattacharya Indranil¹,Brailoiu Eugen¹,Damjanović Marlen¹,Brailoiu G. Cristina¹,Gao Xin¹,Mueller-Guerre Laurence¹,Marjon Nicole A.¹,Gut André¹,Minotti Roberta¹,Meyer Matthias R.¹,Amann Kerstin¹,Ammann Emerita¹,Perez-Dominguez Ana¹,Genoni Michele¹,Clegg Deborah J.¹,Dun Nae J.¹,Resta Thomas C.¹,Prossnitz Eric R.¹,Barton Matthias¹

Affiliation:

1. From the Departement für Innere Medizin (E.H., I.B., M.D., L.M.-G., A.G., R.M., M.R.M., E.A., A.P.-D., M.B.), Klinik und Poliklinik für Innere Medizin; and Klinik für Herz- und Gefässchirurgie (M.G.), Universitätsspital Zürich, Switzerland; Department of Pharmacology (E.B., G.C.B., X.G., N.J.D.), Temple University School of Medicine, Philadelphia, Pa; Department of Cell Biology and Physiology (N.A.M., T.C.R., E.R.P.) and University of New Mexico Cancer Center (E.R.P.), University of New Mexico...

Abstract

We found that the selective stimulation of the intracellular, transmembrane G protein–coupled estrogen receptor (GPER), also known as GPR30, acutely lowers blood pressure after infusion in normotensive rats and dilates both rodent and human arterial blood vessels. Stimulation of GPER blocks vasoconstrictor-induced changes in intracellular calcium concentrations and vascular tone, as well as serum-stimulated cell proliferation of human vascular smooth muscle cells. Deletion of the GPER gene in mice abrogates vascular effects of GPER activation and is associated with visceral obesity. These findings suggest novel roles for GPER in protecting from cardiovascular disease and obesity.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.108.190892

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