Why So Few New Cardiovascular Drugs Translate to the Clinics

Author:

Vatner Stephen F.1

Affiliation:

1. From the Department of Cell Biology and Molecular Medicine, Rutgers-New Jersey Medical School, Newark.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference17 articles.

1. Believe it or not: how much can we rely on published data on potential drug targets?

2. Differences in beta 3-adrenergic receptor cardiovascular regulation in conscious primates, rats and dogs.;Shen YT;J Pharmacol Exp Ther,1996

3. Beta(3)-adrenoceptor agonist-induced increases in lipolysis, metabolic rate, facial flushing, and reflex tachycardia in anesthetized rhesus monkeys.;Hom GJ;J Pharmacol Exp Ther,2001

4. Cardiovascular Control Mechanisms in the Conscious State

5. Improvement of Cardiac Function by a Cardiac Myosin Activator in Conscious Dogs With Systolic Heart Failure

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