Induced Pluripotent Stem Cells in Cardiovascular Drug Discovery-Reference-Cited by-同舟云学术

Induced Pluripotent Stem Cells in Cardiovascular Drug Discovery

Published:2013-02 Issue:3 Volume:112 Page:534-548
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circ Res

Author:

Mercola Mark¹,Colas Alexandre¹,Willems Erik¹

Affiliation:

1. From the Sanford-Burnham Medical Research Institute and the Department of Bioengineering, University of California, San Diego, La Jolla, CA.

Abstract

The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells exhibiting inherited traits and disorders. Use of these cells in high throughput analyses should broaden our insight into fundamental disease mechanisms and provide many benefits for patients, including new therapeutics and individually tailored therapies. Here we review recent progress in generating induced pluripotent stem cell-based models of cardiovascular disease and their multiple applications in drug development.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.111.250266

Reference117 articles.

1. Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

2. Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

3. Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

4. Reprogramming of human somatic cells to pluripotency with defined factors

5. Technical Challenges in Using Human Induced Pluripotent Stem Cells to Model Disease

Cited by 100 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advancing Human iPSC-Derived Cardiomyocyte Hypoxia Resistance for Cardiac Regenerative Therapies through a Systematic Assessment of In Vitro Conditioning;International Journal of Molecular Sciences;2024-09-05

2. Characterizing PFAS hazards and risks: a human population-based in vitro cardiotoxicity assessment strategy;Human Genomics;2024-09-02

3. Advancing Cardiovascular Drug Screening Using Human Pluripotent Stem Cell-Derived Cardiomyocytes;International Journal of Molecular Sciences;2024-07-21

4. In vitro to in vivo extrapolation from 3D hiPSC-derived cardiac microtissues and physiologically based pharmacokinetic modeling to inform next-generation arrhythmia risk assessment;Toxicological Sciences;2024-06-19

5. Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells;Lab on a Chip;2024