1. From the Population Health Research Institute, Hamilton, Ontario, Canada (M.C., J.W.E., J.H.); the Department of Medicine, McMaster University, Hamilton, Ontario, Canada (M.C., J.W.E., J.I.W., J.H.); Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada (J.W.E., J.I.W.); AstraZeneca R&D Mölndal, Mölndal, Sweden (D.G.); and the Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands (M.C.).