His Bundle Recordings in Patients with Bundle Branch Block and Transient Neurologic Symptoms

Abstract

His bundle electrograms were recorded in 19 patients with bundle branch block (BBB) and transient neurologic symptoms allowing for determination of intra-atrial (P-A), atrioventricular (A-V), nodal (A-H) as well as infranodal conduction (H-Q) times. The patients were initially monitored in a coronary care unit and have been followed for a mean period of 8 ± 4 months. In six patients (Group I) neurologic symptoms were observed in the absence of electrocardiographic evidence of A-V block. In six patients (Group II) the cause of symptoms was uncertain; two of these patients had relief of symptoms after permanent cardiac pacemaker insertion and were presumed to have episodic high grade A-V block. In seven subjects (Group III) complete A-V block was documented as the cause of the symptoms; these patients were studied when 1:1 antegrade A-V conduction returned. There was no significant difference between mean P-A, A-H, and QRS durations among the patients in the three groups. Mean H-Q (89 ± 20 msec) for Group III was significantly longer than that for Group I (56 ± 9 msec) or Group 11 (64 ± 11 msec) ( P < .001). All patients with presumed or documented episodes of high grade A-V block had abnormal H-Q intervals, and six of the nine patients with presumed or documented complete A-V block had H-Q intervals >80 msec. The present data suggest that patients with transient neurologic symptoms, bifascicular or left BBB associated with marked prolongation of H-Q (≧80 msec), should be seriously considered as candidates for insertion of a permanent cardiac pacemaker even in the absence of documented high grade or completeA-V block.