1. From the Department of Cardiology (D.M.J., M.M.J.d.J., H.J.G.M.C., P.G.A.V.), Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands; and AstraZeneca Research & Development (L.G.C.), Bioscience, Mölndal, Sweden.