1. From the Department of Bioengineering (A.G.E., S.P., J.H.O., A.D.M.), Department of Pharmacology (S.M., J.H.B.), University of California, San Diego, La Jolla; Department of Pharmacology, University of California, Davis (E.G., D.M.B.); and Simula Research Laboratory, Center for Biomedical Computing, Lysaker, Oslo, Norway (J.E.H., P.L.).