Venous Thromboembolism Does Not Share Strong Familial Susceptibility With Ischemic Stroke

Author:

Zöller Bengt1,Li Xinjun1,Ohlsson Henrik1,Sundquist Jan1,Sundquist Kristina1

Affiliation:

1. From the Center for Primary Health Care Research, Region Skåne and Lund University, Malmö, Sweden (B.Z., X.L., H.O., J.S., K.S.); and Stanford Prevention Research Centre, Stanford University School of Medicine, Stanford CA (J.S.).

Abstract

Background— Coagulation allelic variants associated with venous thromboembolism (VTE) have been suggested to be involved in the pathogenesis of ischemic stroke. This nationwide study aimed at determining whether VTE shares familial susceptibility with ischemic stroke. Method and Results— The Swedish Multigeneration Register of 0- to 75-year-old subjects was linked to the Swedish Hospital Discharge Register and the Cause of Death Register for the period 1987 to 2007. Odds ratios (ORs) for VTE and ischemic stroke were determined in 2 ways: odds of ischemic stroke in offspring whose parents had been diagnosed with VTE, and odds of VTE in offspring whose parents had been diagnosed with ischemic stroke. The analyses were repeated for siblings and spouses. Offspring of parents with VTE (n=25 929) were at increased risk for ischemic stroke (n=5595): OR, 1.10 (95% confidence interval [CI], 1.06–1.14). Siblings of probands with VTE (n=45 132) had no increased risk of ischemic stroke (n=1716): OR, 1.05 (95% CI, 1.00–1.11). Spouses of probands with VTE (n=24 106) were at increased risk for ischemic stroke (n=940): OR, 1.18 (95% CI, 1.10–1.27). The risks for VTE in relatives of probands with ischemic stroke were OR, 1.15; 95% CI, 1.10–1.21 (offspring); OR, 1.07; 95% CI, 1.02–1.12 (siblings); and OR, 1.21; 95% CI, 1.11–1.32 (spouses). Conclusions— VTE does not share strong familial susceptibility with ischemic stroke in the Swedish population. Moreover, familial nongenetic factors contribute to the observed weak familial associations. The present study suggests that it is unlikely that strong shared disease-causing mutations exist to a large extent in the Swedish population.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Genetics (clinical),Cardiology and Cardiovascular Medicine,Genetics

Cited by 16 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3