A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations

Author:

Marroni Fabio1,Pfeufer Arne1,Aulchenko Yurii S.1,Franklin Christopher S.1,Isaacs Aaron1,Pichler Irene1,Wild Sarah H.1,Oostra Ben A.1,Wright Alan F.1,Campbell Harry1,Witteman Jacqueline C.1,Kääb Stefan1,Hicks Andrew A.1,Gyllensten Ulf1,Rudan Igor1,Meitinger Thomas1,Pattaro Cristian1,van Duijn Cornelia M.1,Wilson James F.1,Pramstaller Peter P.1

Affiliation:

1. From the Institute of Genetic Medicine (F.M., I.P., A.A.H., C.P., P.P.P.), European Academy, Bolzano, Italy; Institute of Human Genetics (A.P., T.M.), Technical University of Munich, Munich, Germany; Institute of Human Genetics (A.P., T.M.), Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany; Genetic Epidemiology Unit (Y.S.A., A.I., B.A.O., J.C.W., C.M.v.D.), Department of Epidemiology and Clinical Genetics, Erasmus Medical Centre, Rotterdam, The...

Abstract

Background— We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. Methods and Results— We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133 , a G-protein–coupled receptor (rs885389, P =3.9�10 −8 ). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P =2.00�10 −10 ) and with a region on chromosome 13 (rs2478333, P =4.34�10 −8 ), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval. Conclusion— Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP .

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Genetics(clinical),Cardiology and Cardiovascular Medicine,Genetics

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