1. From the Department of Medicine, Division of Cardiology (E.J.C., H.G.) and Department of Pharmacology (A.L.W.), Columbia University College of Physicians and Surgeons, New York, NY; Department of Medicine, Division of Cardiovascular Disease and Hypertension, Rutgers University New Brunswick, NJ (J.C.); and Department of Medicine, Cardiovascular Sciences, Imperial College London, United Kingdom (N.S.P.).