1. From the Duke Clinical Research Institute (S.M.A.-K., X.M., L.G.Q., S.S., P.L.H., L.H.C.), Department of Medicine (S.M.A.-K., C.F.-M., S.S., P.L.H., L.H.C.), Duke University School of Medicine, Durham, NC; and Department of Cardiovascular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH (B.L.W.).