1. From the Department of Cardiology, St Bartholomew’s Hospital, Bart’s & The London NIHR Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Queen Mary, University of London, London, United Kingdom (R.J.H., T.J.B., I.D., R.K., L.R., V.B., F.G., V.S., E.D., S.P.P., W.U., M.D., M.J.E., S.S., R.J.S.); and International Centre for Circulatory Health, St Mary’s Hospital, Imperial College London, London, United Kingdom (B.U., J.M.).