1. From the Department of Cardiology (C.J.W.B., L.v.E., R.J.v.B., E.T.v.d.V., E.v.d.W., J.J.B., M.J.S.), the Department of Clinical Epidemiology (F.R.R.), and the Department of Thrombosis and Hemostasis (F.R.R.), Leiden University Medical Center, Leiden, The Netherlands.