1. From the Pharmaceutical Development Research Laboratories (T.M., I.K., Y.O., J.M., W.Y., Y.I., A.Z., T.K.), Teijin Institute for Bio-Medical Research, Teijin Pharma Limited, Tokyo, Japan; the Pharmaceutical Research Department (N.H., R.M., J.K., N.I., T.Y.), Biological Research Laboratories, Nissan Chemical Industries, Limited, Saitama, Japan; and the Department of Pharmacology (T.O., H.N.), Graduate School of Medicine, Chiba University, Chiba, Japan.