Affiliation:
1. Department of Physiology, University of Ottawa, Ottawa, Ontario, Canada
Abstract
The following changes were observed in hypophysectomized rats, 14 days after the operation: greatly reduced cardiac output, bradycardia, slight increase in total peripheral resistance, less work done by the left ventricle, low blood pressure, reduced respiratory rate and oxygen uptake, no change in blood volume and erythrocyte count. During an increased input or resistance load, the output and work of the heart rose greatly both in normal and in hypophysectomized rats. The maximum work which the heart did under these conditions, especially if the size of the heart was taken into consideration, was not significantly less in hypophysectomized than in normal rats. It is concluded that the low cardiac output after hypophysectomy is not primarily of cardiac origin.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Reference36 articles.
1. The effect of ablation of the hypophysis upon the weight of the kidney in the rat;MCQUEEN-WILLIAMS M.;Yale J. Biol. Med.,1940
2. Die Rolle der Hypophyse bei der Regulierung von Arbeitsvermogen und Masse des Herzens. Schweiz. med;HAJDU I.;Wchnsehr.,1945
3. THE EFFECT OF DIFFERENT DEGREES OF SUBDIAPHRAGMATIC AORTIC CONSTRICTION ON HEART WEIGHT AND BLOOD PRESSURE OF NORMAL AND HYPOPHYSECTOMIZED RATS
4. BRATJN-MENENDEZ E.: La pression arterielle des chiens sans hypophyse. Comptes rend. Soe. de Biol. I l l : 477 1932.
5. Blood pressure and reaction to histamine in rat after hypophysectomy and adrenaleetoiny;WYMAN L. C;Am. J. Physiol.,1937
Cited by
39 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献