1. From the Departments of Anatomy and Embryology (F.E.A., A.C.G-d.G., C.J.V.M., B.H., L.S.J.v.V., R.E.P., M.C.D.R.), Human Genetics (A.E.S., K.W.v.D.), General Internal Medicine (L.M.H., K.W.v.D.), and Cardiology (L.M.H.), Leiden University Medical Center, Leiden, The Netherlands; TNO-Quality of Life (L.M.H.), Gaubius Laboratory, Leiden, The Netherlands.